Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated With Bilateral Hyperaldosteronism

Genotype-specific Steroid Profiles Associated 3 with Aldosterone-producing Adenomas

Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas.

Primary aldosteronism comprises 2 main subtypes: unilateral aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia. Somatic KCNJ5 mutations are found in APA at a prevalence of around 40% that drive and sustain aldosterone excess. Somatic APA mutations have been described in other genes (CACNA1D, ATP1A1, and ATP2B3) albeit at a lower frequency. Our objective was to identify genoty...

Giant adrenal adenoma with hyperaldosteronism.

1. Adrenal tumor. (A) Abdominal computed tomography showed a large mass with smooth margin, 6.0 cm in diameter, in the left adrenal gland. No sweling of the lymph nodes around the tumor was observed. (B) An adenoma measuring 7.5×6.0×5.5 cm and weighing 122 g with a smooth surface was removed. Its cut surface was golden yelow. (C) HE stain ×20. The adenoma was encapsulated. The adjacent normal a...

A Case of Virilizing Adrenocortical Adenoma

SUMMARY A 2/12 Year-old boy with IsoSexual Pseudoprecocious puberty due to a Virilizing Adrenocortical adenoma is presentecl, who was crronously treated as CAH for 9 months. Prevalence, clinical presentation, diagnosis and differential diagnosis of these tumors are discussed briefly.

Bilateral Adrenocortical Masses Producing Aldosterone and Cortisol Independently

A 31-year-old woman was referred to our hospital with symptoms of hypertension and bilateral adrenocortical masses with no feature of Cushing syndrome. The serum aldosterone/renin ratio was elevated and the saline loading test showed no suppression of the plasma aldosterone level, consistent with a diagnosis of primary hyperaldosteronism. Overnight and low-dose dexamethasone suppression tests s...